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KMID : 0379120160440020122
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Korean Journal of Mycology
2016 Volume.44 No. 2 p.122 ~ p.125
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Phelligridin D from Phellinus baumii Reduces Boar Sperm Viability
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Yi Young-Joo
Lee In-Kyoung
Seo Dong-Won
Yun Bong-Sik
Lee Sang-Myeong
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Abstract
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Phelligridin D (Phe D) is a compound isolated from Phellinus baumii, which is known for various biological activities. In this study, the authors examined the effect of Phe D on boar spermatozoa for its potential application in assisted reproductive technology for mammals. Sperm motility and deubiquitinylating activity significantly decreased when boar spermatozoa were incubated with Phe D (>0.5 μM). The fluorescence intensities of dead sperm, and reactive oxygen species production increased after sperm incubation in the presence of Phe D. Although Phe D is associated with antioxidant and free radical scavenging activity, sperm viability deteriorated after its addition. This could lead to fertilization failure, including that following artificial insemination or in vitro fertilization. Phe D might have other biological functions in spermatozoa, and therefore requires additional studies in the future.
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KEYWORD
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Boar, Phelligridin D, Phellinus baumii, Spermatozoa, Viability
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